AIM:To compare the differences of the intraocular pressure(IOP) measured by four methods:non-contact tonometer (NCT),Goldmann applanation tonometer (GAT),dynamic contour tonometer (DCT) and Pentacam three-dimensional anterior segment analyzer,and to study the relationship between these measuring methods with central corneal thickness (CCT) and central corneal curvature (CCV).METHODS:After measured CCT and CCV by Pentacam system,the IOP of 143 patients (286 eyes) which would be treated by LASIK operation was measured by NCT,GAT and DCT respectively.Then 5 methods were used:Ehlers,Shah,Dresden,Orssengo/ Pye and Kohlhaas proposed by Pentacam system to correct the IOP which was measured by NCT.Finally analysis of variance(ANOVA),correlation and linear regression analysis were adopted to evaluate the IOP data.RESULTS:IOP of DCT was the highest.There was significantly different between DCT and other methods (P<0.01);There was difference between GAT and DCT,Kohlhaas,Shah (P<0.05) and no difference between GAT and other methods;Each group IOP had good correlation,GAT and DCT had strongest correlation (r=0.702);CCT had more influences on NCT IOP,CCV had more influences on GAT,there was no correlation between DCT,Dresden,Orssengo/ Pye,Shah and CCT,CCV (P>0.05).CONCLUSION:The healthy persons with normal CCT and CCV are recommended using applanation tonometer for glaucoma screening.The suspected patients whose CCT and CCV are departure from normal are suggested to check farther by DCT or to correct IOP by Pentacam system.