AIM:To compare Wavelight Allgegrotto Wave Eye-Q and Zeiss Meditec MEL 80 Excimer Lasers about corneal ablation depth after customized aspheric ablation to correct mild and moderate myopia.METHODS:Prospective comparative study.58 cases(108 eyes) with myopia were randomly divided into two groups.31 cases(55 eyes) in group A were treated by Lasik with Wavelight Allgegrotto Wave Eye-Qand the other 27 cases(53 eyes) in group B were treated by Meditec Mel 80.The patients in group A were divided into group A1 and A2 according to the shortsighted degree,representing mild and moderate subsets respectively.The patients in group B were divided into group B1 and B2 as well.Both excimer lasers applied Q-index optimized ablation profile.Moria M2 Automatic Microkeratome was used to operate corneal flap.Treatment zone diameter and optical zone diameter were uniform in all cases.Corneal thickness were measured before and 1 month after surgery.Multiple independent sample mean used single-factor analysis of variance statistically.RESULTS:The actual corneal ablation depth and the theoretical corneal ablation depth didn’t differ significantly in A1 and A2(P=0.081,0.444).The actual corneal ablation depth was less significantly than theoretical corneal ablation depth in B1 and B2(P=0.000,0.000).The theoretical corneal ablation depth in group A1 was significantly less than that in group B1(P=0.001) and similar in moderate subset groups(P=0.000).Actual corneal ablation depth was no different between group A1 and B1(P=0.832)and similar in moderate subset groups(P=0.884).CONCLUSION:Wavelight Allegretto Wave Eye-Q and Mel 80 excimers laser have similar actual corneal ablation depth.Theoretical corneal ablation depth in group A has no difference from the actual one and can be used to predict postoperative corneal thickness exactly.Theoretical corneal ablation depth in group B is much more than the actual one.