AIM:To investigate the long-term effect of the nursing care based on differentiation of symptoms and signs on the Vogt-Koyanagi-Harada’s syndrome (VKH).METHODS:Ninety-six patients with VKH were randomly divided into an experimental group (48 cases,treated with conventional therapy and nurse combined with nursing care based on differentiation of symptoms and signs) and a control group (48 cases,treated with conventional therapy and nurse).After that,the differences in long-term effect between two groups were compared.RESULTS:There were significant differences in long-term effect between the experimental group (the excellent effect:40 cases;the inferior excellent effect:7 cases;the bad effect:1 cases) and the control group (the excellent effect:30 cases;the inferior excellent effect:15 cases;the bad effect:3 cases).Long-term effect in experimental group was significantly better than that in control group (P<0.05).CONCLUSION:The nursing care based on differentiation of symptoms and signs possesses important long-term clinical application value for the patients with VKH.