AIM:To investigate the possible correlation of the clinical parameters including two surgical techniques(combined phacoemusification and IOL implantation and noncombined surgery),different kinds of tamponade(infusion fluid,gas,silicone oil) and different follow-up time with the intraocular pressure(IOP) and visval acuity(VA),and provide a reference for clinical selection of surgical approach and evaluation of efficacy.METHODS:The prospective consecutive non-comparative interventional case series study included 56 patients(57 eyes) who accepted 23-gauge transconjunctival sutureless vitrectomy(TSV23G) combined with cataract surgery or not.Clinical evaluations were performed preoperatively,postoperatively at 1 day,1 month and 3 months.Multiple linear regression were used to analysis VA and IOP.RESULTS:VA was negatively correlated with gas and silicon oil tamponaded,but positively correlated with postoperative 1 month and 3 months(P=0.0005,0.0006,0.0461,0.0210).IOP was positively assoicated with combined surgery and gas tamponade,while negatively with postoperative 3 months(P=0.0038,0.0023,<0.01).CONCLUSION:Although combined surgery may elevate IOP,VA outcome is an inspiration to both doctor and patient.VA of gas or silicon oil tamponaded eyes are usually not good,IOP of the gas tamponaded eyes tend to elevate at early stage postoperatively.Considering to recovering time,VA elevate by time and IOP elevate at early stage postoperatively and decline since the postoperative 3 months.3 months after surgery is the appropriate time to evaluate postoperative efficacy.