Cataract is one of the most common eye diseases causing blind,glutathione S-transferases(GSTs) are typical multifunctional enzyme,which can catalyze the combination of various chemical agents and glutathione.Recent studies have shown that GSTs have effect on anti-oxidant which can lead to the cataract.The expression of GSTs plays an important role in the process of cataract formation.This article reviewed the recent advances in the researches on GSTs system and age-related cataract.