Recently,it becomes a hot study focused on transforming growth factor-β(TGF-β),as a kind of cytokine,whose biological effect and mechanism of action play an important role in corneal fibrosis and healing after surgery especially in excimer laser refractive surgery.Through some signal transduction passageway such Smad,TGF-β plays positive effect on accelerating cell proliferation,promoting extracellular matrix formation and inducing cell migration.Now we review TGF-β about its structure,receptor,signal transmission,distribution in eye,biological action and its relationship with corneal wound healing for excimer laser refractive surgery.