AIM:To observe the efficacy and safety of domestic latanoprost in treating with open-angle glaucoma and ocular hypertension.METHODS:By using randomized,single blind control trial,90 patients with open angle glaucoma or ocular hypertension were divided into 3 groups randomly,30 patients in each group.They were treated by 0.05g/L domestic latanoprost,0.05g/L imported latanoprost and 0.04g/L travoprost respectively for 4 weeks,one drop,once daily evening.RESULTS:After two weeks,there was no statistical significance in terms of post-treatment intraocular pressure(IOP) difference among three group(P=0.673).After four weeks,there was no statistical significance in terms of IOP reduction difference among three groups at each time point.Four patients(13%)with conjunctival hyperemia were in experiment group,three(10%)in control group 1 and eight(27%)in control group 2.CONCLUSION:Domestic latanoprost is safe and can effectively lower IOP of patients with open angle glaucoma and ocular hypertension,which may provide new choice for treatment.