AIM:To observe the clinical effects of methylprednisolone systemic and local application for uveitis.METHODS:Eighty-six 86 cases(157 eyes) of uveitis patients were analysed retrospectively and treated at the Ophthalmology Department of the First Hospital of China Medical University.Methylprednisolone 500-1 000 mg was transfused per day for stoss during the first 3-5 days,and then changed to prednisone 1mg/kg·d orally,and decrement gradually.Methylprednisolone 40mg was locally applicated by injection behind the eyeball during the first 3-5 days,and then decrement gradually,adjusting the medication according to patient’s condition.The best-corrected visual acuity(BCVA),the recovery of uveitis and exudative detachment of retina by ophthalmoscope,the fluorescence leakage of FFA and macular retinal thickness by OCT were observed before and after the treatment.RESULTS:At the end of the follow-up period,the BCVA improved in 128 eyes(81.5%),remained unchanged in 16 eyes(10.2%),and degraded in 13 eyes(8.3%);the uveitis and retina detachment were recovery in 149 eyes(94.9%);the leakage of FFA were no or little in 131 eyes(83.4%);the macular retinal thickness by OCT examination were lower in 134 eyes(85.4%),14 eyes(8.9%) were unchanged and 9 eyes(5.7%) were aggravated.CONCLUSION:The systemic and local application of methylprednisolone for uveitis is effective,which can effectively control the uveitis and improve visual function.