AIM:To evaluate the feasibility and reliability of the digital photorefraction device refitted from the pocket-sized digital camera in the vision screening of infants.METHODS:One hunderd infants aged from 6 months to 72 months were screened by the digital photorefraction device.The results were compared with clinical examination and retinoscopy.RESULTS:The specificities of the simple device in hyperopia,myopia,astigmatism,anisometropia,strabismus were:96.46%,95.29%,96.75%,98.97%,100%,and the sensitivities were:82.76%,93.33%,84.78%,75.00%,100%.CONCLUSION:The simple device is characterized by high sensitivity,good reliability,high specificity,simple operation,low price,easy popularization.It could be used for vision screeing of children.It is applicable to establish and popularize the family mode of vision screening.