AIM:To investigate the clinical effects on reducing the corneal ingury and recurrence of pterygium by combined using of preoperative Xiongfansan and intraoperative biological amniotic membrane transplantation.METHODS:Totally 43 patients(56 eyes) with pterygium,including primary 45 eyes and recurrent 11 eyes,were treated with preoperative Xiongfansan and intraoperative biological amniotic membrane transplantation,and followed up 12-18 months.RESULTS:Totally 52 eyes(93%) were cured,and recurrence was in 4 eyes(7%) with primary 2 eyes and recurrent 2 eyes of pterygium.Xiongfansan did not cause severe chemical damage on cornea,the complications including melting necrosis,ulceration and infection did not occur on corneosclera.CONCLUSION:The effects of combined using of Xiongfansan and biological amniotic membrane transplantation on pterygium is well,with quick repair,low recurrence rate and no rejection.It is an ideal method and should be widely used.