AIM:To compare the cycloplegic effect of cyclopentolate hydrochloride and atropine in children with hyperopia.METHODS:Ninety-six children with hyperopia(192 eyes) were subjected to cycloplegic refractometry by cyclopentolate hydrochloride followed with atropine,to compare and analyze the refractive results and systemic side reactions.RESULTS:The effect on refractive results had no significant difference in two medicines(P>0.05).As for incidence rate of systemic side effects,cyclopentolate hydrochloride was lower than atropine(12.5%).CONCLUSION:The cyclopentolate hydrochloride is a powerful,quick and safe cycloplegia medicine,especially for children with hyperopia.