AIM: To observe the optic neuroprotective effects of supplymenting qi and nourishing yin,activating blood and dissolving stagnation Chinese herbs on patient with controlled intraocular pressure after glaucoma surgery and to discuss the correlated mechanism action from hemorheology·METHODS: Sixty patients(99 eyes) were randomly divided into two groups,the treatment group included 30 patients(50 eyes),the control group included 30 patients(49 eyes).The treatment group were treated by supplymenting qi and nourishing yin,activating blood and dissolving stagnation Chinese herbs,while the control group were treated by Yimaikang capsules.In the course of 60 days treatment,the difference of visual acuity,intraocular pressure,visual field(average light sensitivity and average defect),pattern visual evoked potential(LP100,AP100)and hemorheology index were observed and compared·RESULTS: Visual acuity: The central visual acuity of two groups were both improved.The treatment group was better than control group(P<0.05).Intraocular pressure: pre-treatment and post-treatment,there was no statistical significance(P>0.05) between two groups.Visual field(average light sensitivity and average defect): The average light sensitivity and average defect were obviously improved(P<0.01).The treatment group was better than the control group(P<0.01).Pattern visual evoked potential(LP100,AP100): LP100 and AP100 were obviously sensitive(P<0.01).The treatment group was more sensitive than the control group(P<0.01).Hemorheology: In the treatment group,there were obviously statistical significance(P<0.01) on blood viscosity high-shear,erythrocyte electrophoresis,plasma viscosity,index of erythrocyte aggregation between pre-treatment and post-treatment,there was statistical significance(P<0.05) on blood viscosity hypo-shear between pre-treatment and post-treatment.Post-treatment.There were statistical significance(P<0.05) on blood viscosity high-shear,blood viscosity hypo-shear,erythrocyte electrophoresis,plasma viscosity,index of erythrocyte aggregation between the treatment group and the control group·CONCLUSION: Supplymenting qi and nourishing yin,activating blood and dissolving stagnation Chinese herbs have good efficiency on the optic neuroprotection in the treatment of the cases with glaucoma of controlled intraocular pressure,can elevate visual acuity,enhance average light sensitivity and average defect of visual field,enhance electrophysiology activity of optic nerve,and improve ocular hemorheology.These effects result from improving blood flow supply of optic nerve.