Diabetic retinopathy(DR)is one of the common and severe complications in patients with diabetes,which is the leading cause of impairment of vision in diabetic patients.In recent years,following advanced research of diabetic etiopathogenesis,further advances in pharmacotherapy have shown promise in the treatment of DR,including corticosteroids,vascular endothelial growth factor(VEGF) inhibitors,protein kinase C(PKC) inhibitors,renin-angiotensin system blockers Candesartan and fenofibrate.This review will focus on DR present and potential future pharmacologic treatments.