AIM:To observe the curative effect of mouse nerve growth factor combined with methylprednisolone therapy on acute optic neuritis·METHODS:A total of 55 optic neuritis inpatients who were admitted to our hospital from 1999 to 2011 were retrospectively analyzed·RESULTS:The efficient rate of treatment group was 90.6% and the efficient rate of control group was 69.7%.The result showed that curative effect of treatment group was better than that of control group(P<0.05)·CONCLUSION:With good effect,the treatment of mouse nerve growth factor combined methylprednisolone is a better method for acute optic neuritis.