AIM:To discuss the curative effect,safety and predictability of treatment in different degree myopia by laser epithelial keratomileusis(LASEK)·METHODS:Analyzing method:The different level myopia patients with complete materials were analyzed retrospectively after LASEK treatment of 184 cases(367 eyes) based on clinical records in our hospital·RESULTS:After following up three groups of the patients more than half a year,we discovered that 90.5% of the cured eyes’ error range were within ±0.50D,98.6% within ±1.00D,and the efficiency index was 0.96,the safety index was 1.02.The group of light degree(<-3.00D)had 42 eyes,100% of the eyes’ error range were within±0.50D,the efficiency index was 1.02,the safety index was 1.04.The group of medium degree(-3.00——6.00D)had 123 eyes,95.1% of the eyes’ error range were within±0.50D,100% within ±1.00D,the efficiency index was 0.98,the safety index was 1.02.The group of high degree(>-6.00D)had 202 eyes,89.2% of the eyes’ error range were within±0.50D,94.8% within±1.00D,the efficiency index and safety index were 0.88 and 1.00 respectively.There were six cases with complications,and four of them were scale 2 haze,one open angle glaucoma and one refraction regression.Of all the cases,the central corneal thickness nearly reached our expectation.No keratoconus was found on corneal topography·CONCLUSION: It’s of exactitude,safety and predictability for LASEK to treat different degree myopia.