AIM:To evaluate the main reason of the post operative pain of trans-scleral diode laser cyclophotocoagulation and the clinical effects of combined treatment of trans-scleral diode laser cyclophotocoagulation and ibuprofen oral on late neovascular glaucoma(NVG). METHODS:Totally 30 cases(30 eyes) of NVG accepted trans-scleral diode laser cyclophotocoagulation and ibuprofen oral.All cases were followed up for more than 6 months about intraocular pressure (IOP) and early postoperative pain. RESULTS:The average preoperative IOP was 56.23±21.62mmHg, and the average IOP within 24 hours after the manipulation was 31.36±10.01mmHg (t=8.009,P=0.001).The pain of all cases were relieved obviously. There was mild pain in 3 eyes, heavy pain in 18 eyes and severe pain in 9 eyes before operation. There was no pain in 14 eyes,mild pain 9 eyes,heavy pain in 7 eyes within 24 hours after operation. There was no pain in 21 eyes, mild pain in 8 eyes, heavy pain in 1 eye within 72 hours after operation. CONCLUSION:Trans-scleral diode laser cyclophoto-coagulation and ibuprofen oral can alleviate the post-operative pain and lower IOP for late NVG effectively.