AIM:To compare the efficacy of three different treatment methods for neovascular glaucoma (NVG). METHODS:Totally 51 NVG patients (54 eyes)were retrospectively observed and analyzed, according to the different surgical treatment the patients were divided into three groups.Group A, 27 patients (28 eyes)were treated with simple cyclophotocoagulation; Group B, 14 patients (14 eyes) with trabeculectomy and intraoperative mitomycin C (MMC) application 1 week after avastin intravitreal injection; Group C , 10 patients (12 eyes) with vitrectomy and drainage valve implantation 1 week after avastin intravitreal injection.In the treatment of both Group B and C, the whole course of panretinal photocoagulation (PRP) were completed as early as possible. RESULTS:The mean intraocular pressure(IOP) in patients discharged from hospital:Group A,25.75±1.44mmHg, surgical success rate was 21%;Group B was 12.86±1.37mmHg, surgical success rate was 86%;Group C was 16.58±1.85mmHg, surgical success rate was 83%. CONCLUSION:The three methods can all reduce IOP on different levels. But IOP in most patients within a week after cyclophotocoagulation is not in the normal range. Therefore, visualizable eye should not choose the simple cyclophotocoagulation.Anti-vascular endothelial growth factor (VEGF) drugs combined with anti-glaucoma surgery can effectively control the IOP within a week.For the preservation of visual function in patients,it was better than simple cyclophotocoagulation.