AIM: To investigate the leukostasis and expression of ICAM-1 in 10 weeks diabetic mice retina. METHODS:Forty-five C57 mice (20-25g) were randomly divided into two groups. There were twenty-two mice in diabetic group and twenty-three mice in normal group. The leukostasis in diabetic retinopathy was counted and the expression of VEGF and ICAM-1 was studied by Western Blot. RESULTS: Ten weeks postoperatively, the number of leukocyte was significantly high in diabetic retinopathy （P<0.01）.The expression of VEGF and ICAM-1 was significantly increased in diabetic group (P<0.05). CONCLUSION: The no perfusion of retinal blood capillary is related to leukostasis in early diabetic retinopathy.