AIM:To preliminarily evaluate the safety, effectiveness, predictability and stability of LASIK performed on myopia with corneal refractive power more than 47D. METHODS: Thirty cases (50 eyes) of LASIK surgery with corneal anterior surface refractive power more than 47D by Pentacam topography were selected as study group(corneal anterior surface of 12 eyes corresponded partly with the condition of sub-clinical phase of keratoconus,but the height of their posterior surface was normal); Another 30 cases(50 eyes) of LASIK surgery with corneal anterior surface refractive power less than 47D who had no significant difference with study group in preoperative diopter and best corrected visual acuity (BCVA) as control group. Paired observation was conducted on uncorrected visual acuity(UCVA), BCVA, postoperative diopter and corneal topography 1 month, 3, 6 months, 1 year and 2 years after surgery; the comparative contents of corneal topography included: mean of maximum refractive power within 2mm of central radius of the anterior surface, mean corneal refractive power, central island effect; changes of refractive power of posterior surface, loss of postoperative best-spectacle corrected visual acuity(BSCVA).The postoperative complications were recorded. RESULTS: There were no obvious differences in UCVA, BCVA or postoperative diopter between study group and control group 1 month, 3, 6 months, 1 year, 2 years after surgery; corneal topography compared with the preoperative: mean of maximum refractive power within 2mm of central radius and mean corneal refractive power were improved significantly, which was consistent with myopic reduction degree;the number of eyes with postoperative central island effect in two groups was the same; compared with preoperative, refractive power of corneal posterior surface in two groups had no apparent change, and no keratoconus occurred. CONCLUSION: LASIK for myopia only with corneal refractive power more than 47D or corneal anterior surface corresponds partly with the condition of sub-clinical phase of keratoconus, but the height of posterior surface is normal, of better security, effectiveness, predictability and stability within 2 years after surgery. Long-term influence remains to be observed.