AIM:To evaluate safety and reliability of cataract surgery on the patients with cardiovascular disease in the peri-operation period METHODS:A retrospective study was performed in 74 senile cataract patients with cardiovascular disease which were treated by cataract surgery in the past 2 years. RESULTS:Four cases(4 eyes) did not have cataract surgery due to surgical contraindication;70 cases(70 eyes) with cardiovascular disease were treated with cataract surgery monitored by electrocardiography (ECG) and supplied by constant inhalation of low dose oxygen to minimize the surgical risk.5 cases(5 eyes) were treated by extracapsular cataract extraltion (ECCE)+intraocular lens(IOL) implantation and 65 cases(65 eyes) were treated by phacoemulsification with IOL implantation. 3 patients were installed temporary pacemakers before cataract surgery. After follow up for 1 month,65 cases (65 eyes ) had a best corrected visual acuity (BCVA) equal to or more than 0.3 (92.9% ); 4 cases (4 eyes ) had BCVA of 0.05 or less than 0.3 (5.7%); and 1 cases (1 eye) had BCVA less than 0.05 (1.4%). There were no severe complications during the operation. CONCLUSION:Senile cataract patients with cardiovascular disease must be evaluated before surgery. Surgical indications and contraindication must be controlled strictly.The electrocardiographic monitor is a necessary method to the senile cataract patients with cardiovascular disease in the operation.