AIM:To analyze the cause of abnormal blink in children, and to provide a reference for the diagnosis and treatment of such diseases so as to prevent misdiagnosis. METHODS:A comparative analysis was conducted on clinical data of 345 cases of children with "abnormal blink" as the chief complaint treated in department of ophthalmology from January 2008 to August 2010 to draw conclusions. RESULTS:Most treated children with eye organic disease were also associated with tic disorders, and the majority of eye organic diseases was conjunctivitis.The number of cases in children with frequent blinking caused only by mental stress was the least. CONCLUSION: In order to avoid misdiagnosis and treatment confusion and serious physical and psychological harm to children, ophthalmologist should not ignore the tic disorder diagnosis when no eye organic diseases are checked out in children with abnormal blink.