AIM:To observe and research safety, effectiveness and predictability of excimer laser in situ keratomileusis surgery (LASIK) treatments of myopic patients with keloids. METHODS:Prospective consecutive study. Under the consent of Ethics Committee,16 myopic patients (32 eyes) with keloids underwent LASIK treatment. Their age ranged from 19 to 29 years (mean 23.6 years). Uncorrected distance visual acuity was 0.05-0.2, best-corrected visual acuity(BCVA) was 0.8-1.2. Routine slit-lamp microscope, Orbscan Ⅱ anterior segment analysis system, intraocular pressure, corneal thickness, computer optometry, cycloplegic retinoscopy, subjective refraction, contrast sensitivity and glare as well as other tests were performed. Operation was performed on one eye first in all patients, then on the contralateral eye when no abnormal responses occurred 3 months later.Postoperative follow-up lasted for 2-6 years, average 5820±4.6 months. RESULTS: Postoperative 2-6 years, visual acuity was equal to or greater than 1.0 in 30 eyes (94%), 0.8 in 2 eyes (6%). Postoperative BCVA was greater than or equal to the preoperative in 31 eyes (97%), 1 eye had -0.75D refractive regression. The average difference between postoperative refraction and target refraction was -0.25±0.35 (-0.75~0.75) DS. The corneas were clear, no haze formation or scar healing and no corneal ectasia or corneal thickening occurred. CONCLUSION:LASIK treatment of myopia with keloids is safe and effective. It also shows that the corneal flap and stromal layer are non-scar healing, but a large sample of long-term follow-up is needed for further certification.