AIM:To evaluate the effects of compound anisodine combined with puerarin injection in treatment for ocular fundus ischemic disease. METHODS:The patients of 104 cases were randomly divided into three groups ( combination group 36 cases; compound anisodine injection group 34 cases; puerarin injection group 34 cases) according to retrospective study. RESULTS:After treatment，total effective rate of the combination group, compound anisodine group and puerarin injection group were 92% (33/36)，65% （22/34) and 62% (21/34); There was a great difference between the combination group and the control groups（P<0.05), and no significant difference was found between two control groups（P>0.05). CONCLUSION:Compound anisodine injection combined with puerarin injection has special effects on treating ocular fundus ischemic disease.