To explore the bilviscoelastic materials DisCoVisc and Healon alone on the protection of corneal endothelium in cataract phacoemulsification and foldable intraocular lens implantation. METHODS: Totally 60 cases (60 eyes ) of simple hard nuclear (≥IV nucleus) cataract were divided into two groups, each of 30 cases ( 30 eyes). The first group used bilviscoelastic materials DisCoVisc as observation group; the second group used Healon alone as control group. Observation was conducted on corneal edema of postoperative 1 day , and corneal endothelial cell count of preoperative and postoperative 1 month . RESULTS:The observation group and the control group had a significant difference in the postoperative corneal edema (P<0.01 ) and no difference of statistical significance in corneal endothelial cell loss rate of preoperative and postoperative 1 month (P>0.05 ). CONCLUSION: The application of bilviscoelastic materials DisCoVisc in phacoemulsification of hard nuclear cataract can more effectively protect the corneal endothelium than Healon, reduce postoperative corneal edema, and improve operation safety.