AIM:To investigate the application of Pranoprofen eyedrops in laser epithelial keratomileusis(LASEK) and its clinical value.  METHODS:Totally 300 cases (600 eyes) which had undergone LASEK were examined and randomly divided into two groups, each group had 150 cases (300 eyes). The control group was given Fluorometholone eye drops, experimental group combined with Pranoprofen eye drops. Corneal irritation and haze were compared and observed between these two groups.  RESULTS:In three days after operation, the corneal irritation in the experimental group was significantly reduced compared with the control group (P<0.05), but there was no significant difference in five to seven days after operation (P>0.05). The occurrence of haze in the experimental group was significantly lower than the control group in different stages, and there were significant differences between the two groups in each stage(P<0.05). The incidence of steroid-induced ocular hypertension was 12 cases (4%) in control group and 4 cases (1.3%) in experimental group, and there was significant difference between the two groups (P=0.043).  CONCLUSION: The combined use of fluorometholone and Pranoprofen can significantly reduce the inflammatory response, alleviate corneal irritation at early stage after LASEK, effectively prevent and control the occurrence of haze, and reduce the incidence of steroid-induced ocular hypertension after the operation.