AIM:To observe the value of clinical application of continuous subcutaneous insulin infusion(CSII) with the insulin pump in diabetic patients before and after surgery. METHODS: Fifty diabetic patients (50 eyes) needed to treat with vitrectomy were randomized.27 cases were treated with insulin pump of CSII and 23 cases were treated with daily multi-subcutaneous insulin injection( MSII). The dosage was adjusted according to the blood glucose test results. The differences with the two treatments in blood glucose control level and the time when blood glucose was controlled were compared. RESULTS: Before and after surgical treatment, the two methods were effective in controlling blood sugar to normal or basically normal level, the differences were significant (P<0.05);But the two treatment groups, in the time of blood glucose down to normal, insulin dose and systemic complications,also had significant differences (P<0.01). CONCLUSION: For perioperative diabetes, the clinical application of insulin pump treatment method is better than that of the conventional way of insulin injection.It is a fast, safe and effective treatment method fit for humans physiological function.