AIM：To explore the clinical efficacy of different approaches to the treatment of neonatal dacryocystitis.  METHODS：Totally 386 cases (412 eyes) of neonatal dacryocystitis in outpatient service of our hospital from July 2010 to December 2011 were treated with lacrimal sac massage, irrigation of lacrimal passage and probing combined with drug injection of lacrimal passage to observe the effect of three kinds of therapy and the results were statistically analysed between groups.  RESULTS：Of 412 eyes, lacrimal sac massage cured 97 eyes, the cure rate was 23.5%; lacrimal passage pressure washing cured 98 eyes, the cure rate was 31.1%.Compared with lacrimal sac massage, the difference was statistically significant (P<0.05); Probing combined with drug injection of lacrimal passage cured 213 eyes , the cure rate was 98.2%.Compared with lacrimal sac massage and irrigation of lacrimal passage, the difference was statistically significant (P<0.01). CONCLUSION：Eye lacrimal sac massage therapy in neonatal dacryocystitis is simple, easy, suitable for early treatment; Pressure washing and probing of lacrimal passage can be used in invalid children; Probing combined with tobradex eye ointment injection of lacrimal passage can significantly improve the cure rate of neonatal dacryocystitis ,which can be used as an effective treatment method.