翼状胬肉术后不同处理方法对创面上皮修复的影响
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Effect of two different treatments after pterygium surgery on corneal recovery
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    目的:比较包扎术眼及局部滴用重组人表皮生长因子对翼状胬肉术后角膜上皮修复的影响。 方法:单侧原发性翼状胬肉38例38眼,胬肉侵入角膜在2~5mm范围内。均行翼状胬肉单纯切除术,术后将病例随机分为两组,A组19例术后每日结膜囊内涂氧氟沙星眼膏,绷带包眼至角膜上皮完全愈合;B组19例术后当日给予结膜囊内涂氧氟沙星眼膏包眼,自术后第2d起每日给予氧氟沙星眼水4次+重组人表皮生长因子眼水4次滴眼。对两组病例的角膜情况进行观察,统计角膜上皮完全愈合的时间,进行比较分析。 结果:角膜上皮平均愈合时间A组为4.1±1.4d,B组为65±2.9d,两组间比较有显著统计学差异(P<0.01)。 结论:翼状胬肉术后包眼较局部滴用表皮生长因子眼水更能加快角膜上皮愈合。

    Abstract:

    AIM:To compare packing eyes with recombinant human epidermal growth factor(rhEGF) drops for corneal recovery after pterygium surgery. METHODS:Thirty-eight patients(38 eyes)with unilateral pterygium whose pterygiums had covered cornea surface 2-5mm were chosen. Excisions of pterygium(bare sclera technique) were performed on all of the 38 patients. Then postoperatively those patients were divided into two groups randomly: nineteen eyes in group A were persistently packed with 3g/L ofloxacin ointment until corneal epithelial wound healing; nineteen eyes in group B were packed with 3g/L ofloxacin ointment for 1 day after operation and treated with ofloxacineye drops+rhEGF(20μg/mL) drops 4 times per day from the 2nd day till corneal epithelial wound healing. The changes of cornea were observed postoperatively, the duration of corneal epithelial wound healing was recorded and the differences between group A and group B were compared. RESULTS:The average duration of corneal epithelial wound healing was 4.1±1.4d in group A, and 6.5±2.9d in group B. There was significant statistical difference between group A and B (P<0.01). CONCLUSION:Packing eyes after pterygium excisions could promote corneal epithelial wound healing than using rhEGF drops topically.

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聂丹瑶,姚晓明,黎明.翼状胬肉术后不同处理方法对创面上皮修复的影响.国际眼科杂志, 2012,12(5):991-992.

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  • 收稿日期:2012-02-10
  • 最后修改日期:2012-03-26
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