AIM:To study clinical effects of Erigeron Breviscapus injection combined with retinal laser photocoagulation in the treatment of diabetic retinopathy. METHODS: Totally 50 cases of diabetic retinopathy were treated with Erigeron Breviscapus injection and retinal laser photocoagulation, control group of 50 cases used simple hydroxybenzene sulfonic acid capsules orally. Fundus, visual acuity and blood rheology changes were observed before and after treatment. RESULTS:Erigeron Breviscapus injection and retinal laser photocoagulation therapy could significantly improve vision in patients with diabetic retinopathy, eye microcirculation in patients was markedly improved.Total effective rate was 90%,the differences were statistically significant (P<0.05). CONCLUSION:Erigeron Breviscapus injection combined with retinal laser photocoagulation in the treatment of diabetic retinopathy has good efficacy, to better improve the microcirculation status of diabetic retinopathy, and delays and improves diabetic retinopathy.