AIM: To study the clinical curative effect of compound anisodine injection in treatment of optic nerve contusion. METHODS:Seventy-two cases (72 eyes) with optic nerve contusion that underwent inpatient care in Cangzhou Peoples Hospital between January 2009 and May 2011 were retrospectively analyzed. In the treatment group, 36 cases (36 eyes) were injected compound Anisodine near superficial temporal artery, 36 cases (36 eyes) using conventional drug treatment were as the control group. RESULTS:Twenty-eight days after treatment, the treatment group was significantly better than the control group in the recovery of visual acuity, fundus and visual field. CONCLUSION: Compound Anisodine injection is an effective and easy treatment of optic nerve contusion.