AIM：To study the expression of β-arrestin1 in the spleen cells of experimental autoimmune uveitis (EAU). METHODS: The mice were injected into the foot with IRBP R16. On day 3, the spleen was extracted and the single celI suspension was made. Immunohistochemistry and RT-PCR were done on these spleen cells. RESULTS: The expression of β-arrestin1 on the spleen cells of EAU groups was much higher than that in the normal groups. CONCLUSION: β-arrestin1 might play an important role on the EAU.