Anisometropic amblyopia is a decrease in the best-corrected visual acuity in one eye, resulting from significantly different refractive errors in the patients two eyes. Early intervention in the critical period of vision development is important for the treatment. The orthodox treatment was occlusion of the dominant eye, however, it was influenced by age and the compliance. It is reported that amblyopia was difficult to be cured after the critical period. With the development of clinic research, there has been hope in the treatment of adult and adolescent anisometropic amblyopia. Orthodox occlusion, reflection surgery, and perceptual learning have played roles in the treatment. This article made a review for treatment in adult and adolescent anisometropic amblyopia.