AIM:To discuss the fundus angiography of central serous chorioretinopathy (CSC), including fundus fluorescein angiography (FFA),indocyanine green angiography(ICGA),and synchronous spectral domain optical coherence tomography(SDOCT) in order to investigate the pathogenesis of CSC. METHODS: Fifty-four cases with CSC in our hospital during June 2009 to October 2011 were checked by using Spectralis HRA-OCT. PatientsFFA,ICGA and synchronous SDOCT were analyzed and explained. RESULTS:FFA of 54 cases with CSC appeared retinal pigment epithelial(RPE)fluorescein leakage,ICGA appeared choroidal vascular abnormal in lesions and SDOCT appeared neuroepithelial serous detachment. Comparing FFA with SDOCT of 38 cases（70.4%）, FFA appeared fluorescein leakage where ICGA was small pieces RPE detachment. CONCLUSION:CSC patients disorder location can be diagnosed accurately by checking FFA,ICGA and synchronous SDOCT, which provides clinical data for CSC pathogenesis in order to better guide clinical treatment.