AIM:To observe the clinical effect of phacoemulsification combined silicone oil removal in eyes with silicone oil temponade complicated cataractin diabetic retinopathy. METHODS:Twenty-two cases(22 eyes) with diabetic retinopathy after silicone oil temponade complicated cataract were performed phacoemulsification and intraocular lens implantation combined silicone oil removal. All eyes were transplanted soft intraocular lenses smoothly by corneal transparent incision. RESULTS:Visual acuity of 19 eyes improved after phacoemulsification, 13 cases were better than 0.1, 3 cases were similar with that before. Posterior capsule remained complete intraoperatively, and all eyes smoothly transplanted soft intraocular lenses. Corneal edema occurred in 5 cases, then regressed in postoperative 3-7 days. 22 cases were removed silicone oil smoothly. 3 cases occurred vitreous hemorrhage in postoperative 1 month, among which 2 cases spontaneously absorbed in 4 weeks, 1 case was performed vitrectomy combined with intraocular laser coagulation. 22 cases did not occur retinal re-detachment. CONCLUSION:Phacoemulsification combined silicone oil removal for the treatment of eyes with silicone oil temponade complicated cataractin diabetic retinopathy is not only effective, but also reduces pain caused by repeated operations.