AIM:To investigate the clinical curative effects of lower eyelid retraction patients treated by porous polyethylene lower eyelid spacer (Medpor LES) and homologous sclera transplantation. METHODS:Twenty-six cases with lower eyelid retraction were implanted with a Medpor LES or homologous sclera. Follow-up lasted for 3 months. RESULTS:Three months after surgery the clinical results of both groups were similar. However, 2 cases treated with Medpor LES or homologous sclera demonstrated insufficient lower eyelid retraction correction. There were no significant complications associated with the use of Medpor LES or homologous sclera in this study including infection and rejection. CONCLUSION:This trial shows that the use of Medpor LES or homologous sclera in the lower eyelid was safe. A good or satisfactory final outcome in the majority of cases was verified by the two operation methods. The clinical curative effects of the two groups were not significantly different.