AIM:To evaluate the safety, efficacy of retrograde lacrimal intubation for treatment of chronic dacryocystitis. METHODS:This study included 42 cases (42 eyes) with chronic dacryocystitis from December 2009 to December 2011. The procedure of retrograde intubation was performed in local anesthesia. All cases were received retrograde lacrimal intubation, and the tube was removed after placing 3-6 months. The efficacy and the complication were observed. RESULTS:All operations on patients were conducted successfully, and the tube was removed after placing 3-6 months. 40 out of 42 caess the lacrimal were unobstructed when the tube was removed. 6 months after the tube was removed, the effective rate was 88%.3 cases occurred complication. CONCLUSION: The results show that retrograde lacrimal intubation is a safe, easy and effective method on treating chronic dacryocystitis, which is suitable for clinical application.