目的:临床观察DuoVisc黏弹剂对白内障超声乳化术中低密度角膜内皮细胞的保护效果。方法:观察12例角膜内皮细胞密度为652.9～930.3个/mm²的白内障超乳手术眼,术前记录角膜内皮细胞密度、中央角膜厚度,行白内障超声乳化吸出及后房型折叠人工晶状体植入术,术中应用DuoVisc黏弹剂,术后观察角膜内皮细胞变化,计算术后7d内角膜内皮细胞密度及中央角膜厚度。结果:术后早期部分角膜轻度水肿,药物治疗后恢复透明,术后7d内角膜内皮细胞密度为735.6±92.6个/mm²,较术前（798.2±113.1个/mm²）无明显减少(P=0.145),中央角膜厚度（0.53±0.02mm）正常,同术前（0.51± 0.014mm）相比差异无统计学意义(P=0.144)。结论:熟练掌握超声乳化术的情况下,应用DuoVisc黏弹剂行角膜内皮细胞密度低者的白内障超声乳化术是可行的。

AIM:To observe the protective effects of DuoVisc viscoelastic materials on low density corneal endothelium during cataract phacoemulsification and intraocular lens(IOL) implantation.METHODS:Twenty eyes of cataract with corneal endothelial cell density of 652.9-930.3/mm² were observed. Before the surgery, the corneal endothelium density and central corneal thickness were recorded, then the patients underwent cataract phacoemulsification and IOL implantation in the capsular, the changes were observed during 7days postoperatively.RESULTS:In the early days after the surgery, 4 of these corneas were with mild edema, after medical treatment, they returned transparent. During postoperative 7days, the corneal endothelium cell densities after the surgery(735.6±92.6/mm² )were not statistically less than before(798.2±113.1/mm², P=0.145), the thickness of the central corneas were normal(0.53±0.02mm), which had no statistical significance compared with preoperatively(0.51±0.014mm, P=0.144).CONCLUSION:In the condition of mastering the technique of phacoemulsification, it is feasible to use DuoVisc viscoelastic materials in the surgery of cataract phacoemulsification and IOL implantation with low density corneal endothelium.