目的:评价玻璃酸钠滴眼液对干眼病患者的角膜表面规则性的影响。方法:应用Humphrey角膜地形图仪检测,对结果为可疑圆锥角膜和亚临床期圆锥角膜的患者52例91眼行SchirmerⅠ试验及泪膜稳定性检查,滴玻璃酸钠滴眼液后再行角膜地形图检测,观察角膜表面不规则指数(corneal irregularity measurement, CIM)、形状因子(shape factor, SF)、角膜曲率平均值(mean toric keratometry, TKM)等角膜地形图参数的变化。结果:其中54眼Schirmer试验试纸湿长<10mm或者泪膜破裂时间<10s,滴玻璃酸钠后CIM和SF与用药前比较有显著差异（P<0.01）,TKM与用药前比较无统计学意义（P>0.05）；37眼Schirmer试验及泪膜稳定性试验结果正常,滴玻璃酸钠后CIM,SF,TKM与用药前比较无统计学意义（P>0.05）。结论:玻璃酸钠可通过改善角膜表面光滑度有效降低角膜地形图结果的假阳性率。

AIM:To evaluate the effect of sodium hyaluronic eye drops on the regularity of corneal surface in dry eye patients.METHODS:We examined 52 cases (91 eyes) who were disbelieved as keratoconus or keratoconus at sub-clinical stage with SchirmerⅠtest (SⅠt) and tear film stability, then used Humphrey corneal topography system to examine corneal irregularity measurement(CIM), shape factor(SF) and mean toric keratometry(TKM) before and after instillation of sodium hyaluronic eye drops.RESULTS:The results of SⅠt were less than 10mm and BUT less than 10s in 54 eyes, there were obvious differences of CIM and SF before and after instillation of sodium hyaluronic（P<0.01）, and no obvious differences of TKM before and after instillation of sodium hyaluronic（P>0.05）. The results of SⅠt and tear film stability were normal in 37 eyes, there were no obvious differences of CIM, SF and TKM before and after instillation of sodium hyaluronic.CONCLUSION:Sodium hyaluronic eye drops can smooth the corneal surface and reduce the false positive rate of corneal topography.