AIM:To study the clinical effect of compound anisodine hydrobromide injection for the treatment of anterior ischemic optic neuropathy (AION) on microperimetry.METHODS:Totally 66 cases (107 eyes) with AION were treated by subcutaneous injection of the affected side next to the superficial temporal artery 2mL, 1 time/day, a course of 10 days. The basic courses were 4, according to the condition it can increase 2-3 courses. Fundus optic disc morphology and changes of visual function were observed in order to reflect the clinical value.RESULTS:Vision recovery had significant effect in 55% cases after subcutaneous injection of the affected side next to the superficial temporal artery for 4 courses. The 1^st and 2^nd courses compared with the 3^rd and 4^th courses, visual field defect degrees improved significantly(P<0.05) and the visual function in the 4^th course of subcutaneous injection of the affected side next to the superficial temporal artery recovered best.CONCLUSION:Compound anisodine hydrobromide injection can effectively improve the visual acuity and visual field defect degrees in AION patients, which is convenient, fast and safe.