AIM:To evaluate the antalgic effect of oral gabapendin for postoperative pain after photorefractive keratectomy(PRK).METHODS:Prospective randomized clinical trial at 88 cases undergone PRK. In additional to a standard regimen of topical antibiotics, topical steroids, and topical non-steroid Anti-Inflammatory Drugs (NSAIDs) at all patients, and 40 cases as trial group taken gabapendin protocol for herpes zoster after surgery.Patients completed a maximum pain assessment survey in postoperative 5 days using a pain scale (from zero to four, means 0= no pain,1=mild pain,2=moderate pain,3=severe pain, 4=worst severe pain.). The maximum pain values of postoperative 3 days were recorded.RESULTS:The recovery rate of pain questionnaire was 100%. In gabapendin group, there were 18 cases of 0 degree（45.00%）, 18 cases of 1 degree（45.00%）, 4 cases of 2 degree（10.00%）. In control group, there were 18 cases of 0 degree（37.50%）, 21 cases of 1 degree（43.75%）, 4 cases of 2 degree（8.33%）and 5 cases of 3 degree（10.42%）. Welch's test and Tukey post-hoc test showed no statistic significant difference between the gabapendin groups and control group in maximum pain score（P>0.05）.CONCLUSION:There was no additional contribution to PRK pain control under a postoperative standard regimen by oral gabapendin protocol in our experimental design. 