AIM:To discovery the influence factors of infant dacrocystitis in order to provide science basis to the prevention and treatment of infant dacrocystitis. METHODS:A case-control study including cases and controls, who were matched by age and gender, was carried out in our hospital．Factors were analyzed using conditional Logistic regression.RESULTS:Multivariate analysis showed that birth way, birth order, nation and economic condition were main factors to affect infant dacrocystitis.CONCLUSION:Cesarean section delivery, the first birth, the Han rate and higher economic receive people are the main influence factors to infant dacrocystitis.