方法：从2005/2011年，患有CNDO的儿童235例261眼行鼻泪管探通术。患者按年龄分为3组：组1，131眼为12～24月龄； 组2，82眼为>24～48月龄； 组3，48眼为>48～120月龄。在全身麻醉下进行上、下泪小点探通术。术后1d； 1，2wk； 1，3mo进行随访。通过Mann Whitney U检验和卡方检验分析手术成功率与年龄的相关性。

结果：儿童235例(女性122例，男性113例)的平均年龄为27.6±10.7(12～120)mo。3组患儿一次探通术后的成功率分别为90.1%、85.4%和47.6%，并且组1 、组2成功率显著高于组3(P<0.05)。患儿53例(20.3%)再次行探通术，3组的成功率分别为：61.5%、58.3% 和25.0%。

结论：鼻泪管探通术是治疗CNDO的有效方法，特别是对于小于2岁的患儿。手术成功率随着年龄增加而降低，但是上下泪小管二次探通术可以提高术后效果。

METHODS: A total of 261 eyes from 235 children were treated surgically with probing due to CNDO between 2005 and 2011. Patients were classified into three groups with respect to age. Group 1(12-24 months), group 2(24-48 months)and group 3(48-120 months)consisted of 131, 82 and 48 eyes respectively. Probing was performed for upper and lower punctum under general anesthesia. Postoperative control visits were performed on 1^st day, 1^st and 2^nd weeks, 1^st and 3^rd months. Success rate and correlation with age were analyzed using Mann Whitney U and Chi-square tests.

RESULTS: The mean age for the 235 patients(122 females, 113 males)was 27.6±10.7(12-120)months. The rates of success after one probing in groups 1, 2 and 3 were 90.1%, 85.4% and 47.6% respectively and the procedure was significantly more successful in groups 1 and 2(P<0.05). Probing was repeated in 53(20.3%)patients and rates of success in groups 1, 2 and 3 were 61.5%, 58.3% and 25.0% respectively.

CONCLUSION: Probing is an effective treatment for CNDO especially in children < 2 years of age. Rate of success decreases with advancing age, but second probing and application both through upper and lower canaliculi are measures that may improve the outcome.