AIM:To seek a better drug therapy to control the inflammation after glaucoma surgery through observing the efficacy of using the pranoprofen eye drops before and after the glaucoma surgery.

METHODS:Totally 50 hospitalized cases(52 eyes)with trabeculectomy were randomly divided into 4 groups: a separate use of tobradex eye drops postoperatively(group A), combined tobradex with pranoprofen treatment postoperatively(group B), preoperative 1 day began to use pranoprofen eye drops, combined treatment after the operation group(group C), preoperative 3 day began to use the pranoprofen eye drops and postoperative combination therapy group(group D). Compound trabeculectomy was used as the surgical method. Signs and symptoms of postoperative 1 day, 3, 7, 14, 30 days were observed and scored. SPSS 18.0 statistical software was used for data processing. P <0.05 was considered statistically significant.

RESULTS:Totally 50 cases 52 eyes completed the study. Postoperative 1^st and 3^rd day, comprehensive score of group D was significantly lower than other groups(P<0.05). Comprehensive score of group A at postoperative 3 and 7 days was higher than any other group(P<0.05). Comprehensive score of 4 groups at postoperative 15 or 30 days had no statistical difference(P>0.05).

CONCLUSION: It is a better treatment option that inflammation after trabeculectomy treated by preoperative application of pranoprofen eye drops as pretreatment, postoperative combination of pranoprofen eye drops and glucocorticoid hormones.