AIM: To observe the therapeutic effect of calcium dobesilate and hexuemingmu tablet on non-proliferative diabetic retinopathy(NPDR).

METHODS: Totally 67 diabetic patients 129 eyes were selected. Patients were divided into experimental group and control group. Nonage experimental group was named group A1(16 cases, 29 eyes), nonage control group was named group A2(14 eases, 26 eyes), metaphase experimental group was named group B1(19 cases, 38 eyes), and metaphase control group was named group B2(18 cases, 36 eyes). The patients in experimental group A1 and group B1 took domestic calcium dobesilate and hexuemingmu tablets for 12 weeks. The patients in control group A2 and B2 took rutin tablets, vitamin C and inosine tablets. Three months before and after treatment, the patients' vision, intraocular pressure, the condition of retina, FFA were observed and compared.

RESULTS: After treatment the number of patients with improvement of eye ground in group A1 was significantly more than that in group A2, so was the effective rate(P<0.05)in group B1 was significantly more than that in group B2, so was the effective rate(P<0.05)patients with improvement of eye ground in group A1 was significantly more than that in group B1, so was the effective rate(P<0.05)for early pathological changes.

CONCLUSION: Calcium dobesilate and hexuemingmu tablet is effective on NPDR, which is more obvious for early pathological changes.