AIM: To observe and evaluate the efficacy of wearing orthokeratology lens for anisometropia.

METHODS: Totally 38 patients with anisometropia were fitted with orthokeratology lens. They were followed up 1 day, 1 week; 1 month,3, 6 months; 1 year, 2, 3 years after wearing glasses, and uncorrected visual acuity, corneal curvature, axial length, slit-lamp examination with or without complications were observed.

RESULTS: The uncorrected visual acuity was significantly improved, and it was stable after 1 week. Individual cases with conjunctivitis and punctate epithelial exfoliation could be restored after treatment. Corneal curvature flattened, the average corneal curvature was 43.42±1.17D before wearing glasses, and was 41.65±1.56D one week after wearing glasses, the differences were statistically significant(P<0.01). After wearing glasses for 1 month, 3, 6 months, 1 year, 2 3 years, there were no significant changes. There was no statistically significant difference(P>0.05). After wearing glasses for 1 year, 2, 3 years, the axial length increased by 0.18±0.13, 0.22±0.11, 0.25±0.10mm than before wearing glasses, and there was no statistically significant difference(P>0.05).

CONCLUSION: Orthokeratology appears to be a preferred treatment for juvenile anisometropia, it can correct anisometropia, achieve the balance between two eyes, and it also can effectively control the development of myopia, thereby reducing the gap the degree of anisometropia.