AIM: To evaluate the influence of cardiovascular disease on age-related cataract(ARC).

METHODS: A retrospective case-control study of all the cases(years 2009.09-2011.03)(n=360)and 360 matched controls. The main outcome measures were the odds ratios(OR)and corresponding 95% confidence intervals(CI)of ARC. All subjects were interviewed using a structured interviewer-administrated questionnaire.

RESULTS:No difference was found in age, occupation, residence. After adjustment for multiple potential confounders, the risks of ARC for cases in fasting glucose impaired and diabetes increased 62.4% and 69.8%, respectively(OR=1.624, 95% CI:1.068-2.553, P=0.007; OR =1.698, 95% CI:1.412-2.719, P=0.009). The risk of ARC in hypertension significantly increased(OR=1.431, 95% CI:1.098-1.997, P=0.007). Current smoking and drinking were risk factors of ARC(OR=1.712, 95% CI:1.312-2.344, P=0.010; OR=1.912, 95% CI:1.310-2.896, P=0.003).

CONCLUSION: Diabetes, hypertension, smoking, and drinking have higher risks of ARC, and eventually lead to the occurrence of ARC.