AIM: To compare the effect on central coreal thickness(CCT)after using Travoprost, Latanoprost and bimatoprost.

METHODS: By clinical retrospective case control study, patients with primary open angle glaucoma(POAG)were randomly classified for 3 groups: Twenty patients(22 eyes)were treated with Travoprost, 20 patients(25 eyes)were treated with Latanoprost, and 20 patients(21 eyes)were treated with bimatoprost. CCT before and 6 months after the treatments was observed.

RESULTS: The CCT of 3 groups had decreased markedly after 6 months. Travoprost group decreased from 525±36.45μm to 510±27.87μm(t=8.11, P=0.001), Latanoprost decreased from 30±26.65μm to 512±22.27μm(t=7.34, P=0.001), and Bimatoprost reduced from 534±47.35μm to 516±19.56μm(t=5.62, P=0.001). The effectiveness of the treatments did not differ significantly when the three groups were compared(F=0.205, P=0.544).

CONCLUSION: The study demonstrated that use of prostaglandins could reduce the CCT.