AIM: To observe the clinical curative effect of cyclosporine A eye drops on the treatment of herpetic stromal keratitis.

METHODS: From January 2011 to January 2012, 91 cases 91 eyes with herpes simplex virus keratitis patients in our hospital were randomly divided into two groups: group A received 10g/L cyclosporin A eye drops and ganciclovir gel; group B was used 5g/L loteprednol etabonate ophthalmic solution and ganciclovir gel. The rest were symptomatic treatment. Two groups were followed up for 6-12 months, with an average of 10 months.

RESULTS: There was no significant difference in treatment effect of viral keratitis between two groups. But the average cure time in group A was 5.1±2.4 days, and that of group B was 6.2±2.8 days, indicating that the average cure time in group A was shorter than group B. The two group cure rate and recurrence rate had no statistical difference(P > 0.05).

CONCLUSION For herpes simplex virus keratitis patients, using 10g/L cyclosporin A eye drops can be safe and effective, but the cure time is long.