Diabetic retinopathy(DR)is a serious eye complication caused by abnormal glucose metabolism, and for work people is one of the first blinding eye diseases. Although lots of methods can be used to treat diabetic retinopathy effectively, such as: intravitreal injection, photodynamic therapy(PDT), pars plana vitrectomy(PPV)and so on, but the photocoagulation of retina also is the first choice. With the progress of laser technology, the conventional laser photocoagulation's single-spot pattern could not meet the clinic need, and has gradually been replaced by multi-spot laser, which is more security, effective, less complications. This review focused on current situation of multi-spot laser in diabetic retinopathy.