AIM:To observe the imaging features of the foveal photoreceptor layer in eyes with central serous chorioretinopathy(CSC)using frequency-domain optical coherence tomography(FD-OCT)and to find the relationship between best-corrected visual acuity(BCVA)and the morphology of thickness of the outer nuclear layer.

METHODS: Totally 58 eyes from 54 CSC patients and 60 eyes from 30 healthy volunteers as the control group were selected. FD-OCT scan was performed on all the patients and volunteers. FD-OCT scan of 6mm horizontal line was performed, the scan depth was 1.9mm with a 5.8mm×5.8mm transverse area, the vertical and horizontal resolution was 5μm and 18μm respectively. The scan mode was 512×496. The morphological changes of FD-OCT on different stages of CSC were observed and the relationship between best-corrected visual acuity(BCVA)and the morphology of thickness of the outer nuclear layer were analyzed.

RESULTS: Simple serous neuroepithelial layer detachment and simple serous neuroepithelial layer detachment associated with pigment epithelial layer detachment at macula were about 84.5% of all the patients. Thickness of the outer nuclear layer was thinner from acute stage to chronic stage of CSC, and the relationship between thickness of the outer nuclear layer and BCVA was negative.

CONCLUSION: FD-OCT can detect the detailed morphologic changes and pathological morphology at the foveal photoreceptor layer in eyes with CSC patients.